Suzuki - Miyaura Cross-Coupling Of Cetirizine Impurity A : Synthesis, Charactrization, Molecular Docking And Antioxidant Activity
نویسندگان
چکیده
منابع مشابه
An air stable and efficient palladium catalyst for Suzuki-Miyaura cross coupling reaction at room temperature
The cross-coupling reaction between phenylboronic acid and various types of aryl halides (Suzuki reaction) was carried out using a catalytic amount of a new palladium catalyst (1-benzyl-3-(1-benzyl-1-methylpyrrolidin-1-ium-2-yl) pyridin-1-ium palladium chloride [DBNT][PdCl4]) in poly (ethylene glycol) (PEG-200) in the presence of KOH as the base. This new catalyst was synthesized and...
متن کاملSuzuki-Miyaura cross-coupling optimization enabled by automated feedback.
An automated, droplet-flow microfluidic system explores and optimizes Pd-catalyzed Suzuki-Miyaura cross-coupling reactions. A smart optimal DoE-based algorithm is implemented to increase the turnover number and yield of the catalytic system considering both discrete variables-palladacycle and ligand-and continuous variables-temperature, time, and loading-simultaneously. The use of feedback allo...
متن کاملPalladium-Catalyzed Suzuki–Miyaura Cross-Coupling in Continuous Flow
Carbon–carbon cross-coupling reactions are among the most important processes in organic chemistry and Suzuki–Miyaura reactions are the most widely used protocols. For a decade, green chemistry and particularly catalysis and continuous flow, have shown immense potential in achieving the goals of “greener synthesis”. To date, it seems difficult to conceive the chemistry of the 21st century witho...
متن کاملInsight into Transmetalation Enables Cobalt-Catalyzed Suzuki–Miyaura Cross Coupling
Among the fundamental transformations that comprise a catalytic cycle for cross coupling, transmetalation from the nucleophile to the metal catalyst is perhaps the least understood. Optimizing this elementary step has enabled the first example of a cobalt-catalyzed Suzuki-Miyaura cross coupling between aryl triflate electrophiles and heteroaryl boron nucleophiles. Key to this discovery was the ...
متن کاملCopper(i)-catalyzed sulfonylative Suzuki-Miyaura cross-coupling.
Using a simple copper(i) catalyst has allowed a high yielding sulfonylative-Suzuki-Miyaura cross-coupling reaction to be developed. The process provides a single step route to diaryl sulfones from the direct combination of aryl boronic acids, sulfur dioxide and aryl iodides, and represents the first sulfonylative variant of a classic cross-coupling reaction. Sulfur dioxide is delivered from the...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Pharmaceutical Negative Results
سال: 2022
ISSN: ['0976-9234', '2229-7723']
DOI: https://doi.org/10.47750/pnr.2022.13.s02.33